Crosby played for the third time since being cleared for action. He had missed almost a full year on the ice due to concussion-related symptoms.
In his three games back, Crosby has piled up seven points -- five on assists.
After Kaspars Daugavins scored for Ottawa just 79 seconds into the contest, the Penguins ran off four goals in less than 8 minutes.
Marc-Andre Fleury made 24 saves to get the win.
Craig Anderson was removed from the Ottawa goal after giving up four scores on eight shots. The Senators finished a six-game road trip at 3-2-1.
Notable deaths of 2014 [PHOTOS]