Lynch picked up 88 rushing yards to back Tarvaris Jackson, who went 14-of-24 passing for 148 yards, one touchdown and two interceptions for the Seahawks (4-6).
Sam Bradford was held to 181 yards, a touchdown and a pick-off on 20-of-40 efficiency for the Rams (2-8).
St. Louis running back Steven Jackson managed only 42 yards on 15 carries in the loss.
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