The Packers (10-0) tied for the best start in franchise history with the victory, equalling the mark of the 1962 team, thanks in part to Jordy Nelson's six receptions for 123 yards.
Tom Crabtree caught a touchdown pass while James Starks added 53 yards on six grabs to with 38 rushing yards on 11 carries as Green Bay extended its winning streak to 16 games stretching back to last year.
The Buccaneers (4-6), meanwhile, dropped their fourth straight game despite 132 receiving yards and nine catches from Kellen Winslow.
Josh Freeman went 28-of-38 through the air for 342 yards and two touchdowns, but Green Bay's Tramon Williams intercepted him twice.
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