Major league officials on Tuesday announced the umpiring assignments.
Layne has earned 13 post-season assignments. This year will mark his second World Series. He worked the 2005 series between the Chicago White Sox and Houston Astros.
Also on the crew will be Gary Cederstrom, Ted Barrett, Greg Gibson, Ron Kulpa and Alfonso Marquez. Cederstrom was on the 2005 World Series crew with Layne while Marquez worked the 2006 series and Barrett called the 2007 World Series.
Gibson and Kulpa will be working their first World Series.
All six worked the division playoff series earlier this month.
The World Series is set to begin Wednesday with the Texas Rangers playing the St. Louis Cardinals in St. Louis.