Pujols blasted a two-run shot in the first inning to set the tone, adding a two-run double in the third and another run-scoring two-bagger in the fifth for Cardinals, who banged out 17 hits.
Edwin Jackson started and surrendered two runs over 4 1/3 innings while Lance Lynn (1-0) picked up the victory after working out of a two-on, one-out jam in the fifth.
Milwaukee's Shawn Marcum (0-1) was roughed up for five runs -- all driven in by Pujols -- on seven hits over four frames.
Rickie Weekes smacked a two-run homer and Prince Fielder added a solo shot for the Brewers, who will look to bounce back Wednesday in Game 3 at St. Louis.
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