Williams will undergo surgery on the muscle after sustaining the injury during the first quarter of Sunday's 25-20 loss to Oakland, Texans head Coach Gary Kubiak said.
The linebacker -- the first overall pick by the Texans in the 2006 NFL Draft -- has 241 tackles and 53 sacks in his career, having missed only three of a possible 85 NFL games during the span.
Rookie linebacker Brooks Reed will take Williams' place in the starting lineup, Kubiak said.
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