Collins left last week's game with concussion-like symptoms.
Indianapolis is 0-3 and only four teams have scored fewer points this season. The Colts are 29th in total offense and 27th in passing. Collins has completed 48-of-98 passes for 481 yards, two touchdowns and one interception. His quarterback rating is 65.9.
Painter is 5-of-11 for 60 yards in seeing spot action. He took over for Collins in the fourth quarter Sunday.
The Colts also have Dan Orlovsky on their roster at quarterback. He signed with the team as a free agent July 30.
Collins was an emergency signing in late August when Indianapolis was concerned Peyton Manning, who underwent neck surgery in May, wouldn't be ready for the season. It has since been determined Manning needed additional surgery, which took place Sept. 8. It is unknown if he will be able to play this season.