Excerpts from "Sweetness: The Enigmatic Life of Walter Payton" by author Jeff Pearlman released Wednesday allege the Bears star cheated on his wife, used drugs and suffered from depression, WLS-TV, Chicago, reported.
The Hall of Fame running back died in 1999 from a rare liver disease.
Payton's widow, Connie, says she won't read the unauthorized biography but disputed some of the allegations, including that Payton would use a cocktail of Tylenol and Vicodin to ease the pain after taking hits in games.
"I didn't see him take any Tylenol so I didn't see anything stronger than that," she said. "He didn't believe in taking medicine."
Connie Payton also disputes allegations of an affair and points out the Paytons lived separate lives the last 10 years of their marriage.
She is in the process of writing her own memoir, WLS-TV said.