Suisham's kick came after a 10-play, 60-yard drive highlighted by Mewelde Moore's 22-yard pass reception and run to the Indianapolis 41-yard line.
Pittsburgh's Troy Polamalu recovered a fumble by Colts quarterback Curtis Painter and returned it 16 yards for a touchdown with 5:13 remaining in the game, giving the Steelers a brief 20-13 advantage.
But Painter responded by marching the Colts 80 yards in 10 plays, capped by a 6-yard Joseph Addai touchdown run with 2:09 left.
Kerry Collins started at quarterback for Indianapolis (0-3) and gained only 93 yards on 13-of-29 passing before leaving the game in favor of Painter, who finished 5-of-11 for 60 yards.
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