Charles was injured Sunday in Kansas City's game against Detroit. While Coach Todd Haley didn't say what the injury was, he did say Charles would be out for the year. Charles reportedly suffered a torn anterior cruciate ligament in his left knee.
Charles has started 19 of the 49 games he's played for the Chiefs, rushing for 3,027 yards and 12 touchdowns since he was taken in the third round of the 2008 draft. Last season he rushed for 1,467 yards and was selected for the Pro Bowl.
Kansas City promoted wide receiver Jeremy Horne from the practice squad to fill Charles's place on the active roster. Horne played in three games for the Chiefs last season as a rookie free agent.
Kansas City (0-2) is at San Diego (1-1) Sunday for its next game.