Jed Lowrie drove in four with a three-run shot and an RBI single, while Dustin Pedroia went 3-for-4 with four runs batted in for the American League wild card-leading Red Sox, who split the twinbill with the Orioles.
The Game 2 win was only the fifth in 18 contests for the Bosox and enabled them to remain two games ahead of Tampa Bay in the wild-card chase with eight games to play.
Scott Atchison (1-0) earned the win with 1 1/3 frames of scoreless relief after starter John Lackey was pounded for eight runs on 11 hits over just 4 1/3 innings.
O's starter Brian Matusz (1-8) lasted only 1 2/3 innings, surrendering six runs on six hits.
Swim Week Miami Beach 2014 [PHOTOS]