Brees completed 26-of-37 passes, and Devery Henderson compiled 103 yards and a score on three receptions for the Saints (1-1).
The Saints shut down Chicago's aerial game, holding Jay Cutler to just 19-of-45 passing for 244 yards.
Matt Forte made 10 receptions and ran for 49 yards on 10 carries, totaling 117 yards for the Bears (1-1).
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