The second-year defensive back hurt his left knee in the Chiefs' season-opening loss to Buffalo. He reportedly suffered a torn ACL.
"I won't go into details, but I will say it appears he's going down for the season," Haley said.
The coach called Berry a "special player" and said the rest of the Chiefs will have to player harder "to counterbalance that loss."
"I just know we lost one of our best players and that hurts," he said.
Berry made 92 tackles while starting all 16 games as a rookie. He also had four interceptions.
He reportedly had signed a six-year contract last year worth $60 million, with $34 million guaranteed.