Arencibia, batting for Mike McCoy, followed by lining a 3-1 pitch to left, plating Johnson and giving Toronto a win in the middle contest of a three-game weekend series at Rogers Center.
Jesse Litsch (6-3) earned the victory despite allowing a go-ahead RBI double to Vladimir Guerrero (3-for-4) in the eighth.
Toronto starter Henderson Alvarez yielded three runs on nine hits over seven innings and Jose Bautista socked his 41st homer for the Blue Jays.
Chris Davis contributed a two-run double for the O's.
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