Vettel, the defending Formula One champ, started in pole position and lost the lead only twice and beat Webber by 3.7 seconds.
"The pace was really good in the race, and I was feeling comfortable in the car," said Vettel, who had some concerns about tire blistering after the qualifying laps.
"We had a lot of concerns going into the race after the damage we had on the tires from qualifying," Vettel said. "We took quite a bit of risk, but we had reason to be confident."
Vettel won for the seventh time this season and leads Webber in the Formula One standings by 92 points in the standings.
Jen son Button, driving for McLeran, finished third Sunday.