Blake dispatched Mikhail Kukushkin of Kazakhstan 7-5, 6-1, while Young breezed past German Michael Berrer 6-3, 6-4 to advance.
Also logging victories on Sunday's Day 1 were Germany's Tobias Kamke, Russian Igor Andreev and American Ryan Sweeting.
The top seed at Winston-Salem, the final men's tuneup before the U.S. Open, is American star Andy Roddick.
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