Granderson's two-run double capped a four-run fourth inning that put New York ahead 5-1 and he added a run-scoring single in the ninth as the Yankees managed a split in their four-game series at Toronto.
Hughes (1-2) collected his first win of year after in his second start since returning from the DL with a shoulder injury. The right-hander allowed two runs on four hits in six innings, issuing a pair of walks and fanning five.
Toronto starter Carlos Villanueva (5-2) was touched for five runs on eight hits through six frames.
Travis Snider and Aaron Hill delivered RBIs for the Blue Jays.
Pistorius testifies he didn't consciously pull trigger when he shot girlfriend
Pot vending machine to debut