The Mariners rallied to score the game's final four runs after falling behind 7-4 in the seventh inning, pulling out their season-best sixth straight victory in the first contest of a three-game set.
Wilson and Miguel Olivo singled in the 10th off Anthony Swarzak (0-1), with Wilson going to third on Ichiro's sacrifice. Chone Figgins was intentionally walked and Luis Rodriguez then delivered a sacrifice fly for the lead.
Brandon League made it hold up in the bottom of the 10th, retiring the Twins 1-2-3 to rack up his 11th save. Jamey Wright (1-1) earned with win with a scoreless ninth.
Jim Thome, fresh off the disabled list, bashed two homers for reeling Minnesota, which lost its fourth straight and 13th in 16 games.
LGBT community has 'bullied the American people': Bachmann
Handler slams Piers Morgan: 'You're a terrible interviewer'