The 46-year-old Hopkins (52-5-2) broke the previous record held by ageless George Foreman by a year and laid claim to the WBC belt.
Hopkins had the 26-year-old Pascal largely neutralized by the sixth round and scored stinging punches in the eighth and 10th rounds that put to rest any ideas Jean may have had about a late rally.
Pascal's biggest threat came in the third round when he caught Hopkins with a hard left in the corner of the ring.
The judges scored the bout 116-112, 115-113 and 115-114.
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