Chicago's Marco Pappa broke a scoreless tie in the 43rd minute, redirecting a low cross from Dominic Oduro into the net.
But only 6 minutes later, Akpan responded for Colorado (3-3-1) with his first MLS goal. He took a pass from Omar Cummings inside the area and beat goalkeeper Jon Conway with a shot inside the far post.
The Fire (1-3-3) have gone winless in their last five games.
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