Sedin's second goal, with 10 minutes to go in the third period, gave the Canucks a 4-2 lead. Sedin eluded a pair of defenders, cruised down the slot and fired a wrist shot past Corey Crawford for the eventual game-winner.
Sedin also tallied in the second period and his twin brother Henrik added a pair of assists as the Canucks established a commanding lead heading back to Chicago for Sunday's Game 3.
Jannik Hansen and Alexander Edler scored and Roberto Luongo turned aside 23-of-26 shots for Vancouver.
The defending Stanley Cup champion Blackhawks didn't go down easily. Ben Smith's second goal of game with less than 8 minutes remaining cut Chicago's deficit to one goal, but Luongo shut the door down the stretch.
Viktor Stalberg scored and Crawford finished with 23 saves for the Blackhawks.
Notable deaths of 2014 [PHOTOS]