Busch got a bump from drafting partner and Joe Gibbs Racing teammate Joey Logano during the second green-white-checkered finish attempt and grabbed the lead as the race ended under a caution flag due to a late crash.
Mike Wallace went airborne on the final lap, flipping several times after running into Jason Leffler on the backstretch.
Busch got caught up in an earlier multi-car crash involving a dozen drivers but emerged unscathed. The race featured a record 57 lead changes and 11 cautions.
Third place went to Joe Nemechek and Brad Keselowski finished fourth.
The fifth spot went to pole-sitter Elliott Sadler.