Holliday left the stadium after Thursday's game complaining of a pain in his side. A subsequent examination led doctors to diagnose appendicitis and advise surgery. The procedure was scheduled for Friday.
The Cardinals said they would wait until medical personnel reported before determining "Holliday's return to play status."
Holliday collected three hits, including a home run, in Wednesday's season-opening loss to San Diego.
Holliday, 30, is in his third season with the Cardinals. Over his seven-year career, Holliday has hit .317 with 180 home runs and 695 runs batted in.