Chandler, who had eight points in the game, got the ball after a timeout and knocked down a jumper that broke a 112-112 tie with 29 seconds to play, giving the Nuggets their sixth win in eight games.
Manu Ginobili led San Antonio with 20 points, but missed two shots in the final 13 seconds of the game. Tony Parker had 19 points for Spurs, who lead the Western Conference by six games over the idle second-place Los Angeles Lakers.
The Nuggets erupted for 40 points in the second quarter and held San Antonio to 19 in the fourth quarter.
2014: The Year in Music [PHOTOS]