Booth's 20th of goal of the season, 4 minutes into the game, opened the floodgates for the Panthers, who also got markers from Clay Wilson and Marty Reasoner to post a 3-0 first-period lead.
Florida only got off seven shots the rest of the way but Tomas Vokoun made the lead hold up, turning aside 37-of-39 shots for the Panthers.
Patrick Kane and Marian Hossa each scored in the second period but Chicago could get no closer and saw its eight-game winning streak come to an end.
Starter Corey Crawford was pulled after yielding three goals on eight shots. Marty Turco entered and stopped all seven Florida shots he faced.
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