Booth's 20th of goal of the season, 4 minutes into the game, opened the floodgates for the Panthers, who also got markers from Clay Wilson and Marty Reasoner to post a 3-0 first-period lead.
Florida only got off seven shots the rest of the way but Tomas Vokoun made the lead hold up, turning aside 37-of-39 shots for the Panthers.
Patrick Kane and Marian Hossa each scored in the second period but Chicago could get no closer and saw its eight-game winning streak come to an end.
Starter Corey Crawford was pulled after yielding three goals on eight shots. Marty Turco entered and stopped all seven Florida shots he faced.
2014: The Year in Music [PHOTOS]