Jackson also blocked four shots.
Scoop Jardine added 14 points and eight assists and Dion Waiters added 12 points for the Orange (25-6, 12-6 Big East). Kris Joseph and Fab Melo also hit double figures as Syracuse secured a double-bye in the upcoming Big East Tournament.
The Blue Demons (7-23, 1-17) got 25 points from Tony Freeland and Moses Morgan popped in 16 off the bench for DePaul.
Notable deaths of 2014 [PHOTOS]