Kendall Marshall and Harrison Barnes each chipped in with 10 points and Barnes collected nine boards for North Carolina (20-6, 10-2 ACC), which notched its third straight win despite shooting 36.8 percent from the field.
The Tar Heels led by as many as 13 in the second half but Boston College chipped away, narrowing the deficit to two points at 48-46 when the Eagles' Reggie Jackson connected on a 3-pointer with 1:15 to go.
But Jackson missed a potential game-winning trey in the final seconds and Boston College (16-10, 6-6) came up a bit short.
Jackson and Joe Trapani each finished with 13 points in the Eagles' loss.
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