Laurence Bowers added 16 points and seven rebounds and Ricardo Ratliffe came off the bench to score 10 points with 10 rebounds for the Tigers (21-6, 7-5 Big 12), who ended their road drought against the lowly Cyclones.
Denmon went 9-of-14 from the field for Missouri, which shot 49.1 percent in its seventh straight over win Iowa State.
Jake Anderson led the Cyclones (14-13, 1-11) with 17 points. Calvin Godfrey contributed 13 points and 10 rebounds off the bench in the setback.
Celebrity Families of 2014 [PHOTOS]