Favre finished his second season with Minnesota on the sideline because of injuries and the Vikings ended up with a 6-10 record.
Favre has announced his retirement twice before only to return to play, but his filing of retirement papers would seem to signal the conclusion of his 20-year, Hall of Fame-level career with Green Bay, the New York Jets and Minnesota.
"I know it's time and that's OK," Favre was quoted as saying after Game 16.
Favre has completed 6,300 passes for 71,838 yards with 508 touchdowns and 336 interceptions -- all NFL records. He led the Packers to a Super Bowl win after the 1996 season.