Talib Zanna added 10 points off the bench and Brad Wanamaker chipped in with nine points, seven rebounds and seven assists for the Panthers (17-1, 5-0 Big East), who beat an unranked opponent at home for the 46th straight time.
Travon Woodall's trey gave Pitt a 9-7 lead early in the first half and triggered a 14-4 surge that put the Panthers in control the rest of the way.
Herb Pope scored 15 points and collected 10 rebounds for the Pirates (8-10, 2-4).
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