Collison and Jeff Foster each sank a pair of free throws in the final minute to maintain Indiana's lead after Thaddeus Young's 2-footer with 1:12 remaining had brought the 76ers to within two points at 103-101.
Tyler Hansbrough added 12 points and nine rebounds for Indiana, which broke a nine-game road losing streak.
Jrue Holiday put in 19 points and distributed eight assists as Philadelphia dropped its second straight.
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