Collison and Jeff Foster each sank a pair of free throws in the final minute to maintain Indiana's lead after Thaddeus Young's 2-footer with 1:12 remaining had brought the 76ers to within two points at 103-101.
Tyler Hansbrough added 12 points and nine rebounds for Indiana, which broke a nine-game road losing streak.
Jrue Holiday put in 19 points and distributed eight assists as Philadelphia dropped its second straight.
Astronomers offer more expansive view of universe
McPhee, Cokas 'working on their marriage' after affair