Rose added six assists and Carlos Boozer posted 12 points and 13 rebounds for the Bulls, who completed a 4-0 homestand.
Taj Gibson contributed 16 points and 14 rebounds off the bench while Omer Asik scored 12 in a reserve role for Chicago.
Andrea Bargnani returned to the Toronto lineup after missing four games with a sore calf, scoring 12 points and pulling down six rebounds as the Raptors lost for the eighth time in 10 games.
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