Sharp's 19th goal of the season came on a power-play early in the third period to make it 2-0 Blackhawks. His second marker arrived only 37 seconds after Dave Bolland had made it 3-0 midway through the frame on a power play.
Hossa returned from the injured reserve list to assist on Sharp's first goal and on a first-period tally by Tomas Kopecky.
Marty Turco turned aside 26-of-27 shots for the Blackhawks, who wrapped up a five-game homestand with their fourth straight win.
Derick Brassard got the Blue Jackets' only goal and Mathieu Garon stopped 21 shots in the loss.
Former Titans kicker dies in car crash
UPI Sports Results for September 20, 2014