Houshmandzadeh's touchdown was set up on a fumble by the Browns' Mohammed Massaquoi. Ed Reed also picked off a Colt McCoy pass which led to a 40-yard Billy Cundiff field goal and a 13-7 Ravens lead late in the first half.
Ray Rice rushed for 92 yards on 25 carries for Baltimore (11-4).
McCoy finished 15-of-29 passing for 149 yards, no touchdowns and three interceptions for Cleveland (5-10).
Peyton Hillis was held to 35 yards on 12 carries in the Browns' defeat.
Couple mistakenly served bag of cash at McDonald's drive-thru
Kate Middleton recycles dress at movie premiere