Little, a 22-year-old senior, was charged with misdemeanor battery, criminal damage and criminal trespass. The Lawrence (Kan.) Journal-World reported the arrest stemmed from an alleged altercation between Little and his girlfriend.
"Mario remains a member of our team while we work through this process," Self said in a statement. "But we have suspended him indefinitely from competition while we gather the facts of this incident."
Little has appeared in nine games this season for Kansas and was averaging 6.2 points, 3.7 rebounds and 1.3 assists a game. He had the final key free throw Dec. 7 in the Jayhawks' 77-76 win over UCLA.
Little issued a statement through the school apologizing for "what happened last night." He said, "I accept responsibility for those actions and I apologize to my teammates for being irresponsible."
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