Sidney Crosby picked up an assist in the victory, extending his point streak to 18 games.
Their latest win put the Penguins five games shy of their NHL-record 17-game winning streak set during the 1992-93 season.
Alex Goligoski and Matt Cooke also lit the lamp and Marc-Andre Fleury stopped 34 shots in the win.
Jason Pominville and Tyler Ennis scored and Miller made 19 saves for the Sabres.
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