"I have been a Division I football coach for the last 25 years and, during that time, my primary focus has been making a difference in the lives of the young men I have been so fortunate to have coached and building championship programs," Meyer said in a statement released by the school. "At this time in my life, however, I fully grasp the sacrifices my 24/7 profession has demanded of me, and I know it is time to put my focus on my family and life away from the field.
"I relish the opportunity to cheer for my three terrific kids as they compete in their own respective sports."
Meyer had made a similar announcement a year ago, citing health reasons, only to return for the 2010 season after a leave of absence.
Meyer has a 64-15 record with two national championships in six seasons at Florida. The Gators are 7-5 heading into the Outback Bowl against Penn State.
Meyer, 46, is a three-time national coach of the year with a career record of 103-23, including stints at Bowling Green and Utah. Before becoming a head coach, he was an assistant at Ohio State, Illinois State, Colorado State and Notre Dame.