Ryan Mallett racked up 320 passing yards, connecting on 13-of-23 throws with two interceptions. Mallett broke the school record for career touchdown passes with 60 in Arkansas' win.
The Razorbacks (10-2, 6-2 SEC) took their sixth straight victory thanks, in part, to three receptions for 164 yards and two scores by Cobi Hamilton.
The Tigers (10-2, 6-2), meanwhile, saw their three-game winning streak snapped.
Jordan Jefferson went 16-of-27 passing for 184 yards for LSU and Stevan Ridley rushed for 75 yards and a pair of scores on 17 carries.