Brees connected on 29 of his 43 passes with two interceptions for the Saints (7-3), who took their third straight win to remain a game behind Atlanta in the NFC South.
Chris Ivory rushed for 99 yards and a score on 23 carries for the Saints.
The Seahawks (5-5) got a big game from Matt Hasselbeck, but it wasn't enough for a win. He completed 32-of-44 passes for 366 yards and a score, with six passes going to Mike Williams for 109 yards.
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