Poulter had five birdies on each nine of the Hong Kong Golf Club and is at 13-under 127 halfway through the tournament. Anthony Kang (61) was 6-under on the second nine in his second round and is now in second place at 12-under. Simon Dyson (65) and Rory McIlroy (66) are tied for third two strokes behind Poulter.
First-round leader Mark Brown had consecutive bogeys on Nos. 6-8 en route to a 1-under 69 and dropped to a tie for 10th, four strokes off the lead.
Poulter is yet to make a bogey in the tournament. He set a course record and the tournament 36-hole record, breaking both by one stroke.
Kang closed with birdies over Nos. 16-18.
Poulter was 2-under after six holes before five consecutive birdies on Nos. 7-11. After a par at the 12th hole he had back-to-back birdies. He set the course record with a birdie at the 18th hole.
"It is one of those courses where if you can get off to a good start you really feel you can shoot a good number," Poulter said.
"I had five birdies from the seventh and as soon as that happened I felt there were plenty of chances coming in."