It will be his second knee surgery in three years. Oden was the No. 1 choice in the 2007 NBA draft out of Ohio State and has played in only 82 games.
The team said an examination revealed cartilage damage to the surface of Oden's femur, an injury that is not related to a fractured left patella he suffered last December. Oden has not played since the patella injury.
He also had microfracture surgery on his right knee in September, 2007.
During his limited playing time in two seasons, Oden has averaged 9.4 points and 7.3 rebounds per game.