Vick broke several records in the performance, during which he powered the Eagles to a 28-0 advantage after one quarter and led Philadelphia to the second-most points in club history.
Vick, who completed 20-of-28 throws and added 80 rushing yards, became the first player in NFL history to throw for more than 300 yards, run for more than 50, throw four TD passes and run for two more in the same game.
The Eagles racked up a team-record 592 yards of offense in the lopsided win.
Jerome Harrison gained 109 rushing yards with a touchdown and LeSean McCoy carried 11 times for 43 yards and caught five passes for 51 yards and a score for the Eagles (6-3).
Donovan McNabb was picked off three times for the Redskins (4-5), only hours after he had signed a multi-year contract extension worth a reported $78 million over five years.
Washington's Keiland Williams gained 89 yards and notched two rushing TDs as well as catching four passes for 50 yards and a score.