Creamer, looking for her first win since capturing the U.S. Women's Open this summer, shot a 6-under 66 at the Guadalajara Country Club for a two-day total of 10-under 134.
Cristie Kerr, who had a 64 to lead after one round, was still in front after nine holes Friday but then lost five strokes on the back side. She shot a 76 and wound up in a tie for 14th at 140.
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