Nicks caught six passes for 128 yards for the Giants (6-2).
Brandon Jacobs rushed for 78 yards as New York rolled up 487 yards of total offense and yielded only 162 on defense in their first win at Seattle since 1981.
The Seahawks (4-4) were led by Charlie Whitehurst in his first career start. Whitehurst, subbing for the injured Matt Hasselbeck, completed 12-of-23 passes for 113 yards with a touchdown and two interceptions.
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