The Browns coach indicated injuries to the team's first- and second-string signal-callers could pave the way for the first NFL start for the former Texas Longhorns star.
Mangini said he was "leaning" toward starting McCoy "if Jake and Seneca aren't available but I also want to see how things progress this week."
Wallace started in the Browns' loss to Atlanta Sunday but was injured in the final minute of the second quarter. Delhomme, who had been hobbled by an ankle sprain, replaced him but wound up reaggravating the injury.
The team signed quarterback Brett Ratliff off the New England's practice squad Tuesday.
"I have confidence in Colt and I have confidence in Brett," Mangini said, adding that McCoy would get more practice time this week.