Manning connected on 27-of-42 pass attempts and survived a pair of interceptions, hooking up with Hakeem Nicks for a career-high 12 receptions, good for 130 yards with a pair of scores.
The Texans (3-2), who possess one of the top offenses in the league, were limited to a total of 195 yards by New York.
NFL-leading rusher Arian Foster could manage only 25 yards on 11 carries for Houston.
Ron Burgundy interviews Peyton Manning on SportsCenter
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