Pedroia was put on the 15-day disabled list Saturday with a non-displaced fracture of a navicular bone in his left foot, which he sustained while fouling off a ball in Friday's game against the Giants.
Pedroia will not need surgery, the Red Sox said.
Meanwhile, an examination of Boston pitcher Clay Buchholz revealed a strained left hamstring. The team said he will miss his scheduled start this week but will not be placed on the disabled list after pulling up lame in Saturday's game.
A third Red Sox player injured in the Giants series, catcher Victor Martinez, also won't need surgery for a broken left thumb suffered Sunday, but the team said he is likely to be placed on the disabled list.