The Twins erased a 2-0 deficit with a five-run fourth-inning rally. They hit five singles and Michael Cuddyer added an RBI double in the uprising, giving Minnesota the lead for good in the first contest of a three-game inter-league series at Target Field.
Carl Pavano (7-6) gave Minnesota seven strong innings, surrendering three runs on five hits over seven innings, walking only one and fanning five to get the win.
Aaron Cook (2-4) was touched for five runs on nine hits in 3 1/3 innings.
Todd Helton and Troy Tulowitzki each smacked solo homers in the Rockies' first-ever visit to the new Twins ball park.