Lilly's bid to record the fourth no-hitter in the big leagues this season ended when pinch-hitter Juan Pierre led off the ninth with a solid single to center field. It was only Lilly's second win of the year against five losses.
Carlos Marmol came on in relief to record his 13th save, but not before loading the bases.
The win allowed the Cubs to avoid a sweep by the White Sox in the finale of their three-game inter-league series at Wrigley Field.
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